《消除吧！十二神姬退魔传》是一款结合了【三消】与【构筑】的Roguelike策略游戏，你要携手12位生肖娘，帮助她们抵御来自上古凶兽的入侵。游戏中有丰富的随机事件、战斗、强化等选项，谨慎地选择前进路线、合理地分配资源、让生肖娘变强是打败敌人的关键。
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